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. Author manuscript; available in PMC: 2007 Dec 7.
Published in final edited form as: Neuron. 2006 Dec 7;52(5):831–843. doi: 10.1016/j.neuron.2006.10.035

Figure 7. GluR2(R845A) blocks Aβ-induced loss in spine number.

Figure 7

(A) Apical dendrites expressing indicated constructs (along with EGFP) were imaged with 2PLSM. Scale: 10μm.

(B) Co-expression of APP with GluR2(R607Q) decreases spine density when compared to GluR2(R607Q) expression alone (Spine Density (sp/μm): GluR2(R607Q): 0.65±0.04, 32 dendrites; APP/GluR2(R607Q): 0.51±0.05, 33 dendrites, 4 cells/construct, p=0.036). When GluR2(R607Q;R845A) is co-expressed with APP, there is no difference in spine density when compared to GluR2(R607Q;R845A) expression alone (Spine Density (sp/μm): GluR2(R607Q;R845A): 0.73±0.06, 27 dendrites; APP/GluR2(R607Q;R845A): 0.77±0.05, 29 dendrites; 4 cells/construct, p=0.6). All data are reported as mean ± SEM. p values calculated with t-test. *=p<0.05.