TABLE 1.
Distribution of colorectal cancer cases, controls, and age-adjusted OR (AOR) estimates for subject characteristics and selected colorectal cancer risk factors
| Variable | Cases, n = 1095 |
Controls, n = 1890 |
AOR (95% CI) |
|---|---|---|---|
| n1 (%) | |||
| Age group,2 y | |||
| 20–44 | 71 (7) | 126 (7) | N/A |
| 45–49 | 76 (7) | 105 (6) | N/A |
| 50–54 | 135 (12) | 282 (15) | N/A |
| 55–59 | 172 (16) | 356 (19) | N/A |
| 60–64 | 245 (22) | 400 (21) | N/A |
| 65–69 | 250 (23) | 384 (20) | N/A |
| 70–74 | 145 (13) | 231 (12) | N/A |
| Sex | |||
| Female | 516 (47) | 881 (47) | 1.00 |
| Male | 579 (53) | 1009 (53) | 0.98 (0.84, 1.14) |
| Education | |||
| High school | 638 (59) | 960 (51) | 1.00 |
| College/Bachelor | 331 (31) | 695 (37) | 0.72 (0.61, 0.86) |
| Graduate | 112 (10) | 222 (12) | 0.76 (0.60, 0.98) |
| NSAID use3 | |||
| No | 668 (62) | 1062 (57) | 1.00 |
| Yes | 400 (38) | 804 (43) | 0.78 (0.67, 0.91) |
| BMI 2 y ago (kg/m2) | |||
| <25 | 393 (37) | 769 (41) | 1.00 |
| 25–29.9 (overweight) | 479 (45) | 771 (41) | 1.23 (1.04, 1.45) |
| ≥30 (obese) | 197 (18) | 323 (17) | 1.21 (0.98, 1.50) |
| Family history of CRC in 1st degree relative6 | |||
| No | 781 (71) | 1660 (89) | 1.00 |
| Yes | 312 (29) | 212 (11) | 3.11 (2.56, 3.78) |
| Red meat,4 servings/wk | |||
| 0–2 | 307 (29) | 697 (37) | 1.00 |
| 2.1–3 | 224 (21) | 370 (20) | 1.37 (1.10, 1.70) |
| 3.1–5 | 265 (25) | 417 (22) | 1.45 (1.18, 1.78) |
| >5 | 276 (26) | 378 (20) | 1.67 (1.36, 2.05) |
| Energy intake,5 kcal/d | |||
| ≤1514.0 (Q1) | 201 (19) | 467 (25) | 1.0 |
| 1514.1–1937.0 (Q2) | 259 (25) | 466 (25) | 1.29 (1.03, 1.62) |
| 1937.1–2435.0 (Q3) | 266 (26) | 466 (25) | 1.35 (1.08, 1.69) |
| >2435.0 (Q4) | 310 (30) | 467 (25) | 1.56 (1.25, 1.94) |
| Dietary fiber intake,5 g/d | |||
| ≤17.0 (Q1) | 240 (23) | 466 (25) | 1.0 |
| 17.1–23.3 (Q2) | 258 (25) | 468 (25) | 1.09 (0.87, 1.35) |
| 23.4–30.8 (Q3) | 263 (25) | 466 (25) | 1.09 (0.88, 1.36) |
| >30.8 (Q4) | 275 (27) | 466 (25) | 1.15 (0.93, 1.43) |
1
Numbers may not add to total due to missing values.
2
Age at colorectal cancer diagnosis date for cases and referent date (June 30, 1999) for controls.
3
Took aspirin or ibuprofen-based medications at least twice a week for more than a month.
4
Intake 2 y ago (epidemiology questionnaire); quartile distribution based on controls.
5
Intake 2 y ago (based on Hawaii FFQ); quartile distribution based on controls; 1 kcal = 4.184 kJ.
6
CRC, colorectal cancer.