Table 2.
compd | Seizures (AD50 mg/kg) | Tail-Flick (AD50 mg/kg) | Hot-Plate (AD50 mg/kg) |
---|---|---|---|
1a | 2 (0.5–4) | 12 (2–59) | 15% @ 20 |
1b | 40% @ 50 | 10% @ 30 | 0% @ 30 |
1c | 10 (9–11) | 1.8 (0.4–9) | 13% @ 20 |
1d | 0% @ 50 | 7.0 (3–15) | 25% @ 20 |
1e | 0% @ 50 | 18.3 (10–31) | 7% @ 20 |
1f | 33 (10–113) | 7.0 (2.5–18) | 0% @ 20 |
Dose response curves were determined using a minimum of 4 different doses of test compound and at least eight mice were used per dose group.