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. Author manuscript; available in PMC: 2007 Apr 10.
Published in final edited form as: Annu Rev Cell Dev Biol. 2005;21:223–245. doi: 10.1146/annurev.cellbio.21.122303.120653

Figure 1.

Figure 1

Active transport of mRNAs from the nucleus (left, light blue)to peripheral cytoplasmic destination sites in eukaryotic cells. Transport proceeds through a number of sequential phases as follows: (a) Recognition of cis-acting elements by nuclear trans-acting factors (TAFs) (purple ellipses) and formation of ribonucleotide protein (RNP) complexes; (b) nuclear export of RNP particles and recruitment of cytoplasmic TAFs ( yellow ellipses); (c) motor-based active transport of cytoplasmic RNP particles along cytoskeletal filaments (green and blue lines); (d, f ) association with additional cytoplasmic TAFs, such as anchoring proteins, at destination sites (light green ellipses); (e, f ) recruitment of ribosomes and other translational components (not shown) either before (e)or after ( f ) cytoplasmic translocation; ( g) locally controlled translation.