Skip to main content
. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Mutat Res. 2006 Dec 8;616(1-2):46–59. doi: 10.1016/j.mrfmmm.2006.11.021

Figure 1. Classic Double-strand Break Repair (DBSR) Model.

Figure 1

In the classic model for recombination-mediated DSB repair, invasion of the undamaged template by the exposed 3' ends of both sides of the break junction (indicated by yellow arrows), primes the synthesis of the nascent DNA used for repair and forms a pair of holiday junctions. As indicated in the lower portion of the figure, depending on how these Holiday junctions are resolved, the DBSR model predicts crossover and noncrossover (“gene conversion”) events will occur with approximately equal frequency.