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. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: Cancer Cell. 2006 Dec 28;11(1):9–23. doi: 10.1016/j.ccr.2006.10.019

Figure 5.

Figure 5

Overexpression of Mad2 is not required for tumor maintenance. (A) Axial MR images of the abdomen and the lungs of bitransgenic mice on normal diet (Mad2 on) and after 2 weeks on doxycycline food (Mad2 off) showing the presence of tumors (white arrows). (B) H&E (top) and Ki67 staining (bottom) of a hepatoma in a bitransgenic TetO-Mad2/CMV-tTA mouse untreated (Mad2 on) (left) and a mouse fed doxycycline for 15 weeks after confirming the presence of a tumor by MRI. (C) QRT-PCR confirming the downregulation of Mad2 in the tumor. Black bar 100μm, red bar 20μm and blue bar 1cm.