Table 3.
Serotonin blood levels, urinary peptide excretion rates, and head circumference by TPH2 and GLO1 genotypes. *
| TPH2 | AUTISTIC PATIENTS – RS4570625 | AUTISTIC PATIENTS – RS4565946 | ||||||
| GG | GT | TT | Statistics | CC | CT | TT | Statistics | |
| Serotonin Blood Levels (ng/ml) | 352.4 ± 35.7 (90) | 293.8 ± 40.7 (39) | 261.2 ± 57.0 (6) | F = 0.642 (2,132 df), P = 0.53 | 377.4 ± 64.9 (42) | 328.2 ± 33.2 (58) | 289.1 ± 42.1 (32) | F = 0.742 (2,129 df), P = 0.48 |
| Urinary Peptides (AUC in μm2) | 309.5 ± 122 (80) | 297.5 ± 97.5 (42) | 332.0 (2) | K-W χ2 = 3.340, 2 df, P = 0.19 | 306.0 ± 127.5 (33) | 298.0 ± 86.5 (57) | 296.0 ± 150 (32) | K-W χ2 = 0.172, 2 df, P = 0.92 |
| Head Circumference (percentile) | 82.5 ± 23.7 (97) | 82.5 ± 17.5 (57) | 50.0 ± 24 (6) | K-W χ2 = 2.324, 2 df, P = 0.31 | 75.0 ± 23.7 (42) | 75.0 ± 23.7 (72) | 90.0 ± 23.7 (42) | K-W χ2 = 0.958, 2 df, P = 0.62 |
| GLO1 | AUTISTIC PATIENTS | UNAFFECTED SIBLINGS | ||||||
| AA | AC | CC | Statistics | AA | AC | CC | Statistics | |
| Serotonin Blood Levels (ng/ml) | 213.2 ± 22.5 (49) | 208.5 ± 11.7 (76) | 244.3 ± 24.2 (29) | F = 0.857 (2,153 df), P = 0.43 | 201.0 ± 33.5 (22) | 189.8 ± 29.4 (18) | 177.8 ± 20.9 (10) | F = 0.111 (2,49 df), P = 0.90 |
| Urinary Peptides (AUC in μm2) | 324.0 ± 110 (55) | 313.0 ± 120 (85) | 319.0 ± 132 (37) | K-W χ2 = 0.711, 2 df, P = 0.70 | 212.5 ± 65 (26) | 196.0 ± 98 (25) | 290.0 ± 146.5 (15) | K-W χ2 = 1.363, 2 df, P = 0.51 |
| Head Circumference (percentile) | 82.5 ± 17.5 (63) | 82.5 ± 23.8 (99) | 75.0 ± 33.2 (40) | K-W χ2 = 1.325, 2 df, P = 0.52 | 86.3 ± 19.1 (22) | 82.5 ± 23.8 (22) | 82.5 ± 31.6 (10) | K-W χ2 = 0.788, 2 df, P = 0.67 |
* Data are expressed as mean ± S.E.M. for serotonin blood levels, and median ± semi-interquartilic range for amounts of urinary peptides and head circumference; 2-tail P-values are reported. Sample sizes are shown in italics; K-W = Kruskal-Wallis non-parametric ANOVA.