Table 4.
TPH2 alleles in autistic patients with(+) or without (-) motor stereotypies (MS) or verbal stereotypies (VS).
| SNP | Allele | AUTISTIC PATIENTS | CONTROLS* | |||
| M.S. PRESENT | M.S. ABSENT | V.S. PRESENT | V.S. ABSENT | |||
| rs4570625 | G | 104/148 (70.3%) | 37/54 (68.5%) | 60/82 (73.2%) | 74/110 (67.3%) | 206/268 (76.9%) |
| T | 44/148 (29.7%) | 17/54 (31.5%) | 22/82 (26.8%) | 36/110 (32.7%) | 62/268 (23.1%) | |
| statistics | M.S. + vs -: χ2 = 0.06, 1 df, P = 0.81 | V.S. + vs -: χ2 = 0.78 1 df, P = 0.38 | ||||
| M.S. + vs Controls: χ2 = 2.18, 1 df, P = 0.14 | V.S. + vs Controls:χ2 = 0.47, 1 df, P = 0.49 | |||||
| M.S. - vs Controls: χ2 = 1.69, 1 df, P = 0.19 | V.S. - vs Controls:χ2 = 3.74, 1 df, P = 0.053 | |||||
| rs4565946 | C | 79/153 (51.6%) | 34/64 (53.1%) | 51/95 (53.7%) | 58/113 (51.3%) | 156/268 (58.2%) |
| T | 74/153 (48.4%) | 30/64 (46.9%) | 44/95 (46.3%) | 55/113 (48.7%) | 112/268 (41.8%) | |
| statistics | M.S. + vs -: χ2 = 0.04 1 df, P = 0.84 | V.S. + vs -: χ2 = 0.11, 1 df, P = 0.73 | ||||
| M.S. + vs Controls: χ2 = 1.71, 1 df, P = 0.19 | V.S. + vs Controls: χ2 = 0.59, 1 df, P = 0.44 | |||||
| M.S. - vs Controls: χ2 = 0.55, 1 df, P = 0.46 | V.S. - vs Controls: χ2 = 1.53, 1 df, P = 0.22 | |||||
| Haplotypes | Estimated Frequency in M.S. and/or V.S. present | Estimated Frequency in M.S. and/or V.S. absent | ||||
| G-C | 0.3271 | 0.3065 | ||||
| G-T | 0.458 | 0.4516 | ||||
| T-C | 0.201 | 0.2419 | ||||
| T-T | 0.014 | - | ||||
| Likelihood ratio test: null = -232.5, alternative = -232, LRS = 1.034, 3 df, P = 0.59 | ||||||
*Allelic frequencies for controls are from ref 13.