Table 5.
Case-control, TDT and FBAT (additive model) analyses of SNP C419A (A111E) at the GLO1 locus.
| CASE-CONTROL | ITALIAN PATIENTS (N = 191) | ITALIAN CONTROLS (N = 171) | U.S. PATIENTS (N = 101) | ITALIAN PATIENTS (chr N = 382) | ITALIAN CONTROLS (chr N = 342) | U.S. PATIENTS (chr N = 202) | ||
| A/A | 67 (35.1%) | 52 (30.4%) | 34 (33.7%) | A | 221 (.5785) | 186 (.5439) | 115 (.5693) | |
| A/C | 87 (45.5%) | 82 (48.0%) | 47 (46.5%) | C | 161 (.4215) | 156 (.4561) | 87 (.4307) | |
| C/C | 37 (19.4%) | 37 (21.6%) | 20 (19.8%) | |||||
| Italian patient vs control genotypes χ2 = 0.94, 2 df, P = 0.63 | Italian patient vs control alleles χ2 = 0.88, 1 df, P = 0.36 | |||||||
| TDT | Autistic Patients | Unaffected Siblings | ||||||
| N = 236 complete trios | N = 100 complete trios | Maternal transmissions | Paternal transmissions | |||||
| A Transmitted | 105 | χ2 = 0.074(1df), P = 0.79 |
56 | χ2 = 4.35(1df), P < 0.05 |
21 | χ2 = 1.00(1df), P = 0.32 |
26 | χ2 = 5.16(1df), P < 0.05 |
| C Transmitted | 109 | 36 | 15 | 12 | ||||
| TDT autistic patients vs unaffected siblings: χ2 = 24.48 (1df), P < 0.000001 | ||||||||
| FBAT | Allele | N. of families | S | E(S) | Var(S) | Z | P | |
| Autistic Patients | A | 170 | 199.000 | 206.000 | 61.500 | -0.893 | 0.37 | |
| C | 170 | 189.000 | 182.000 | 61.500 | 0.893 | |||
| Unaffected Siblings | A | 77 | 111.000 | 103.000 | 30.000 | 1.461 | 0.14 | |
| C | 77 | 75.000 | 83.000 | 30.000 | -1.461 | |||
| FBAT autistic patients vs unaffected siblings: Z = 17.44, P < 0.00001 | ||||||||