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. 2007 Mar 7;8:80. doi: 10.1186/1471-2105-8-80

Table 2.

Results for five-study simulation data. True integration-driven discovery rate (tIDR) and true integration-driven revision rate (tIRR) for threshold value of posterior probability of differential expression γ = 0.95, and the number of true discovered genes for posterior expected false discovery rate peFDR = 5%, for the Bayesian standardized expression integration (SEI) and probability integration (PI) models. Results are shown for the three levels of simulated percent differentially expressed genes ps and three levels of mean inter-study variability τg2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@ for the five-study simulation data.

ps = 5% ps = 10% ps = 25%

Five-Study Simulation Data SEI PI SEI PI SEI PI
Low : mean τg2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@= 0.1 (DE); 0.01(non DE) tIRR, γ = 0.95 13.7% 34.7% 3.8% 20.6% 0% 11.4%
tIRR, γ = 0.95 4.5% 0% 6.7% 0.6% 15.4% 1.4%
True Genes, peFDR = 5% 88 106 187 215 496 576

Medium : mean τg2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@= 0.3 (DE); 0.03 (non DE) tIDR, γ = 0.95 7.2% 21.3% 2.2% 15.2% 0% 6.7%
tIRR, γ = 0.95 9.4% 0% 10.2% 3.6% 16.8% 3.0%
True Genes, peFDR = 5% 99 118 212 241 571 642

High : mean τg2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFepaDdaqhaaWcbaGaem4zaCgabaGaeGOmaidaaaaa@30EE@= 0.7 (DE); 0.07 (non DE) tIDR, γ = 0.95 3.8% 13.3% 0% 5.4% 0% 3.4%
tIRR, γ = 0.95 9.8% 0.9% 7.9% 2.8% 10.7% 3.5%
True Genes, peFDR = 5% 122 135 259 270 654 688