Table 2.
Results for five-study simulation data. True integration-driven discovery rate (tIDR) and true integration-driven revision rate (tIRR) for threshold value of posterior probability of differential expression γ = 0.95, and the number of true discovered genes for posterior expected false discovery rate peFDR = 5%, for the Bayesian standardized expression integration (SEI) and probability integration (PI) models. Results are shown for the three levels of simulated percent differentially expressed genes ps and three levels of mean inter-study variability for the five-study simulation data.
| ps = 5% | ps = 10% | ps = 25% | |||||
| Five-Study Simulation Data | SEI | PI | SEI | PI | SEI | PI | |
| Low : mean = 0.1 (DE); 0.01(non DE) | tIRR, γ = 0.95 | 13.7% | 34.7% | 3.8% | 20.6% | 0% | 11.4% |
| tIRR, γ = 0.95 | 4.5% | 0% | 6.7% | 0.6% | 15.4% | 1.4% | |
| True Genes, peFDR = 5% | 88 | 106 | 187 | 215 | 496 | 576 | |
| Medium : mean = 0.3 (DE); 0.03 (non DE) | tIDR, γ = 0.95 | 7.2% | 21.3% | 2.2% | 15.2% | 0% | 6.7% |
| tIRR, γ = 0.95 | 9.4% | 0% | 10.2% | 3.6% | 16.8% | 3.0% | |
| True Genes, peFDR = 5% | 99 | 118 | 212 | 241 | 571 | 642 | |
| High : mean = 0.7 (DE); 0.07 (non DE) | tIDR, γ = 0.95 | 3.8% | 13.3% | 0% | 5.4% | 0% | 3.4% |
| tIRR, γ = 0.95 | 9.8% | 0.9% | 7.9% | 2.8% | 10.7% | 3.5% | |
| True Genes, peFDR = 5% | 122 | 135 | 259 | 270 | 654 | 688 | |