Table 4.
Sensitivity analysis results for the two-study and five-study simulation data. Sensitivity analysis results for the prior degrees of freedom assigned to the slide and experiment effect variance parameters, and , respectively, for the two-study and five-study simulation data sets with medium mean = 0.3 (differentially expressed); 0.03 (non-differentially expressed) and simulated percent differentially expressed genes ps = 10%. Shown are true integration-driven discovery rate (tIDR) and true integration-driven revision rate (tIRR) for threshold value of posterior probability of differential expression γ = 0.95, and the number of true discovered genes for posterior expected false discovery rate peFDR = 5%, for the Bayesian standardized expression integration (SEI) and probability integration (PI) models.
| Two-Study Simulation Data | True Integration-Driven Discovery Rate, γ = 0.95 | True Integration-Driven Revision Rate, γ = 0.95 | True Genes, peFDR = 5% | ||||
| Prior Degrees of Freedom | |||||||
| SEI | PI | SEI | PI | SEI | PI | ||
| 3 | 3 | 10.8% | 16.2% | 15.9% | 4.5% | 185 | 211 |
| 6 | 6 | 4.4% | 11.9% | 11.6% | 1.2% | 197 | 216 |
| 10 | 10 | 3.6% | 10.2% | 7.9% | 0.6% | 202 | 218 |
| 20 | 20 | 1.7% | 8.1% | 4.4% | 0.5% | 206 | 219 |
| 40 | 40 | 1.6% | 6.6% | 5.9% | 0.5% | 208 | 221 |
| Five-Study Simulation Data | |||||||
| 3 | 3 | 2.2% | 15.2% | 10.2% | 3.6% | 212 | 241 |
| 6 | 6 | 0% | 8.8% | 13.0% | 2.8% | 219 | 246 |
| 10 | 10 | 0% | 6.9% | 13.1% | 2.7% | 225 | 248 |
| 20 | 20 | 0% | 3.9% | 14.4% | 3.1% | 228 | 250 |
| 40 | 40 | 0% | 5.1% | 12.8% | 1.8% | 227 | 250 |