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Heparin (Hep) binds and induces dimerization of N1b1b2. (A) N1b1b2 binds to heparin Sepharose, eluting in ≈500 mM NaCl. (B) Size-exclusion chromatography of N1b1b2 reveals that heparin binding induces apparent dimerization of N1b1b2. This dimerization requires a length of heparin >6-mer. (C) Neuropilin-2, N2b1b2, also binds heparin Sepharose, eluting in ≈400 mM NaCl. (D) Heparin induces dimerization of Nrp-2 in a similar fashion to that of Nrp-1.
