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Incidence of brain tumors in PARP-1−/−p53−/− mice. A high frequency of brain tumors was only observed in PARP-1/p53 double mutant mice. All brain tumors were identified by macro- and microscopic examinations. The groups of various genotypes were monitored for 24 weeks and the curves show only brain tumors in various genotypes. The incidence of lymphomas and soft tissue sarcomas were not shown.
