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. 2003 Jan;162(1):329–342. doi: 10.1016/S0002-9440(10)63824-2

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Copyright © 2003, American Society for Investigative Pathology

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Figure 3. — GOM deposits in cerebral blood vessels from 17- to 20-month-old transgenic mice. Ultrathin brain vessel sections from a 19-month-old nontransgenic littermate control (NTg) (A) and from a 17-month-old transgenic mouse (line Ma) (Tg) (B, C) were examined by electron microscopy. Vessel from the transgenic mouse showed no prominent changes but exhibited electron-dense granular deposits corresponding to GOM (arrows) within the basement membrane that are better seen on the higher magnification (C). Higher magnification of a GOM in a transgenic mouse brain vessel (inset, Tg) and of a GOM in a CADASIL patient brain vessel (inset, Hum) showing that GOM deposits in mouse and human had a similar structure. SMC, smooth muscle cell; EC, endothelial cell. Original magnifications: ×1293 (A, B); ×3597 (C); ×27,800 (inset, Tg); ×19,500 (inset, Hum).