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Enhancement of AR activity by CBP in LNCaP (A) and long-term steroid-deprived LNCaP-abl (B) cells. LNCaP cells were transfected with the reporter plasmid pGL3E-probasin and CBP cDNA and treated with R1881 and/or anti-androgens for 24 hours. Luciferase activities are expressed in relation to values measured in CBP-overexpressing cells treated with R1881; dotted bars, cells transfected with empty plasmid; open bars, cells transfected with CBP cDNA.
