Figure 5.
Immunohistochemical detection of CD21-L, α4β7, and CXCR3 of GI-FL, nodal FL, MALT lymphoma. and normal ileum. In contrast to nodal FLs the GI-FLs express α4β7. Neither nodal FLs nor GI-FLs express CXCR3. The T cells surrounding the malignant follicles are CXCR3-positive. Low-grade MALT lymphoma expresses both α4β7 and CXCR3. In normal ileum, all mantle zone lymphocytes strongly express α4β7 and a significant fraction expresses CXCR3. The GC B cells display low, but detectable α4β7 expression but no CXCR3 expression.