Table 4.

Distribution of Mutations in the IgV_H Genes of Three GI FLs

Patient no.	Total no. of mutations*	Observed mutations in the CDR regions			Observed mutations in the framework regions*			P value†‡	P value†§
		R	S	R/S	R	S	R/S
1	40	13	5	2.6	11	11	1.0	0.05	<0.05
2	32	12	5	2.4	8	7	1.2	0.14	<0.05
3	21	5	3	1.7	6	7	0.9	<0.05	<0.05

*Counted starting from codon 23 where the FR1 primer ends.

^†P value; chance that the observed R/S ratio in the Framework Regions (<1.5) had occurred by chance only, ie, in the absence of selective forces.

^‡See Chang and Casali. 42

^§See Lossos et al. 43