Figure 10.

Cytoskeletal and adhesion properties of peripheral blood osteoclasts. Osteoclasts were generated in vitro from controls and patient 1 and processed for fluorescence microscopy as described in Materials and Methods. Actin rings (rhodamine-conjugated phalloidin staining) in control (A) and patient’s (B) osteoclasts. αVβ3 receptor in control (C) and patient’s (D) osteoclasts. c-Src (E) and PYK2 (F) in patient’s osteoclasts. No differences were noted between control and osteopetrotic controls. Original magnifications, ×40.