Table 4.
Validation of TMA for Mismatch Repair Proteins
| ws +, tma + | ws +, tma − | ws −, tma − | ws −, tma + | Total | Concordance | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|---|---|
| MLH1 | 52 | 10 | 19 | 3 | 84 | 85% | 84% | 86% |
| MSH2 | 55 | 2 | 22 | 2 | 81 | 95% | 96% | 92% |
| MSH6 | 23 | 3 | 26 | 13 | 65 | 75% | 88% | 67% |
Staining results of the array compared to results of staining of whole slides from the same patients for MLH1, MSH2, and MSH6.
Staining was scored as either positive or negative, as described above. Tma, tissue microarray; ws, whole slide; +, positive nuclear staining; −, negative nuclear staining; conc, percentage concordance; sensitivity (percentage of true positives), specificity (percentage of true negatives).