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. 2003 Feb;162(2):645–654. doi: 10.1016/S0002-9440(10)63858-8

Figure 5.

Figure 5.

Ghrelin effect on ARO and N-PAP thyroid carcinoma cell line proliferation. Ghrelin treatment determined a dose-dependent inhibition of cell proliferation in ARO and N-PAP cells. At 10 nmol/L, ghrelin was ineffective in both cell lines, whereas 100 nmol/L of ghrelin significantly reduced N-PAP cell proliferation at 96 hours (*, P = 0.01, treated versus control). Ghrelin (1 μmol/L) significantly inhibited ARO and N-PAP cell growth at any time point (*, P = 0.01; **, P = 0.005, treated versus control). Values are mean ± SD of three different experiments with cells seeded in quadruplicate.