Figure 5.

Disruption of cerebella and cortex and neuronal death in the brain of Tat-expressing mice. H&E staining was performed in the sections of brain from wild-type mice treated with Dox (6 mg/ml) for 7 days, GT-tg bigenic mice treated with or without Dox (6 mg/ml) for 7 days, and the GT-tg bigenic mice that died 5 days after initiation of Dox treatment (shown as GT-tg + Dox*). The representative images of A–D were taken from the whole brain section, while the representative images of E–L were taken in the cortex region of the brain.