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. 2003 May;162(5):1475–1486. doi: 10.1016/S0002-9440(10)64280-0

Figure 7.

Figure 7.

Effect of 200 ng/ml of IL13-PE on cellular proliferation in tissue cultures of primary normal, Th1-type, and Th2-type fibroblast lines. Fibroblasts were incubated for 24 hours with 10 ng/ml of IFN-γ or IL-13 for 24 hours before the addition of 100 μl of DMEM-15 alone (control) or the same volume of DMEM-15 containing 200 ng/ml of IL13-PE for another 24 hours. Four hours before the conclusion of the experiment, 10 μCi of [3H] thymidine was added to each well. The proliferation of Th1- and Th2-type but not normal fibroblasts was inhibited after exposure to IL13-PE. ‡‡‡, P ≤ 0.001 compared with Th1-type fibroblasts exposed to media alone. ‡, P ≤ 0.05 compared with Th2-type fibroblasts exposed to media alone. ***, P ≤ 0.001 compared with Th1-type fibroblasts exposed to the same cytokine in the absence of IL13-PE treatment (control). *, P ≤ 0.05 compared with Th2-type fibroblasts exposed to the same cytokine in the absence of IL13-PE treatment (control).