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. 2003 Apr;162(4):1203–1211. doi: 10.1016/S0002-9440(10)63916-8

Table 3.

Biological Functions of DNA Repair Proteins

Proteins DNA repair pathway Functions References
Ku NHEJ Binds to double-strand DNA breaks and activates DNA-PK complex 33-35
OGG1 BER DNA glycosylase/AP lyase involved in the first step of BER 37-39
PARP BER/NHEJ Binds to single- and double-strand DNA breaks and poly(ADP)ribosylates nuclear proteins 40-41
MSH2 MMR Corrects DNA replication errors 42-44
PCNA MMR/NER? Binds to MSH and XPG 45-47

HRR, homologous recombinational repair; NHEJ, nonhomologous end joining; BER, base excision repair; NER, nucleotide excision repair; and MMR, mismatch repair; PCNA, proliferating cell nuclear antigen.