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. 2003 Apr;162(4):1259–1269. doi: 10.1016/S0002-9440(10)63922-3

Figure 2.

Figure 2.

a–e: Nonphosphorylated NFP immunostain with antibody SMI 311. a: In control mice, nonphosphorylated NFP was detected in neurons and dendrites in the gray matter (GM), but not in the white matter (WM) of the thoracic segment of the transverse section. b: One week after DA virus infection, SMI 311+ axonal swelling (arrows) was detected in the NAWM and SMI 311+ axonal retraction balls were visible in the longitudinal section (inset). c: Two weeks after infection, the number of SMI 311+ axons increased. d: Three weeks after infection, the extent of swelling was severe and coarse varicosities on axons (inset) were seen in the longitudinal section. e: One month after infection, significant axonal swelling occurred in the anterior and lateral funiculi. SMI 311+ fragmented and degenerating axons were shown in the longitudinal section (inset). f and g: Immunostain against phosphorylated NFP showed axonal loss in the white matter (arrowhead) during the chronic phase of DA virus infection (f), but not in the control mice (g). Original magnifications: ×110 (a–e); ×45 (f); ×30 (g); ×300 (insets in b, d, e).