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Schematic representation of events as observed in the F344 to LEW and LEW to F344 renal allografts. Transplantation results in shortening of telomeres in all combinations investigated, this results in activation of p21 and p16. However, only in F344 to LEW renal allografts SA β-gal staining is observed, this suggests that an additional event is required to induce cellular senescence.
