Table 5.
Mean percentage mammographic density (MD) according to IGFBP-1 and IGFBP-3 haplotype-tagging SNPs
| SNP | Genotype | n | Mean percentage MDa | p for trendb |
| 15 | G/G | 120 | 26.4 | 0.39 |
| A/G | 452 | 27.3 | ||
| A/A | 548 | 26.2 | ||
| 16 | A/A | 36 | 24.0 | 0.41 |
| A/G | 377 | 28.0 | ||
| G/G | 707 | 26.3 | ||
| 17 | G/G | 56 | 25.3 | 0.75 |
| C/G | 405 | 26.9 | ||
| C/C | 635 | 26.5 | ||
| 18 | A/A | 1 | 11.9 | 0.18 |
| A/G | 59 | 23.8 | ||
| G/G | 1,060 | 26.9 | ||
| 19 | A/A | 158 | 28.4 | 0.006 |
| G/A | 543 | 27.3 | ||
| G/G | 409 | 24.8 | ||
| 20 | T/T | 5 | 21.7 | 0.06 |
| C/T | 97 | 23.6 | ||
| C/C | 1,017 | 27.0 | ||
| 21 | G/G | 120 | 28.2 | 0.81 |
| A/G | 502 | 25.6 | ||
| A/A | 465 | 27.3 | ||
| 22 | T/T | 108 | 28.1 | 0.44 |
| C/T | 441 | 27.1 | ||
| C/C | 557 | 26.3 | ||
| 23 | T/T | 35 | 28.2 | 0.67 |
| C/T | 336 | 26.9 | ||
| C/C | 715 | 26.5 | ||
| 24 | A/A | 195 | 24.8 | 0.55 |
| A/G | 517 | 27.4 | ||
| G/G | 378 | 26.5 | ||
| 25 | C/C | 148 | 25.5 | 0.86 |
| G/C | 511 | 27.0 | ||
| G/G | 383 | 26.3 | ||
| 26 | T/T | 202 | 26.4 | 0.87 |
| T/G | 605 | 26.2 | ||
| G/G | 282 | 26.5 | ||
| 27 | T/T | 49 | 23.4 | 0.80 |
| T/G | 362 | 27.4 | ||
| G/G | 673 | 26.4 | ||
| 28 | A/A | 47 | 27.6 | 0.65 |
| T/A | 359 | 26.2 | ||
| T/T | 700 | 26.9 | ||
| 29 | C/C | 44 | 24.0 | 0.16 |
| T/C | 346 | 26.2 | ||
| T/T | 706 | 27.1 |
IGFBP, insulin-like growth factor binding protein. aMultivariate-adjusted models including age (continuous), body mass index (continuous), alcohol consumption (category), age at first birth/parity, history of benign breast disease (yes/no), family history of breast cancer (yes/no), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal never user, postmenopausal current user, postmenopausal past user); bp for trend based on inclusion of genotype as an ordinal variable in models with square-root-transformed mammographic density as the dependent variable. The result in bold is significant (p ≤ 0.05).