Table 3.
Most cytokines are abundant in high-grade tumors
| Biological markers | Grade I (n = 17) | Grade II (n = 56) | Grade III (n = 32) | P | |||
| IL-1β | 0.8 | (0–260) | 2.6 | (0–102) | 4.7 | (0–194) | 0.025 |
| IL-2 | 0.9 | (0–4.6) | 1.2 | (0–42.6) | 1.4 | (0–6.6) | NS |
| IL-4 | 3.4 | (0–20.1) | 0.6 | (0–30.2) | 3.9 | (0–99.6) | 0.037 |
| IL-6 | 11.7 | (7.8–4,312) | 14.1 | (4.4–190) | 30.6 | (8.8–26,487) | < 0.001 |
| IL-8 | 43.9 | (9.1–11,281) | 35.4 | (0–8,358) | 186 | (0.3–15,890) | < 0.001 |
| IL-10 | 0.2 | (0–1.6) | 0.2 | (0–5.6) | 0.7 | (0–4.6) | 0.030 |
| IL-12 (p70) | 1.4 | (0–5.3) | 2.1 | (0–19.3) | 2.9 | (0.7 -17.2) | 0.045 |
| IL-13 | 4.1 | (3.4–21.4) | 4.2 | (3.0–394) | 4.2 | (1.6–35.5) | NS |
| G-CSF | 13.9 | (7.1–87.3) | 18.9 | (5.3–110) | 22.2 | (9.9–79.2) | NS |
| IFN-γ | 26.8 | (19.8–270) | 25.6 | (17.1–1,279) | 28.7 | (15.5–324) | NS |
| MCP-1 | 96.3 | (22.8–1,208) | 91.3 | (0–22,451) | 201 | (24.4–37,117) | 0.006 |
| MIP-1β | 451 | (44.6–2,674) | 496 | (42.6–14,439) | 776 | (114–13,287) | 0.011 |
| TNF-α | 7.15 | (5.9–28.0) | 7.1 | (5.8–120) | 7.8 | (6.2–37.2) | NS |
Values are expressed as median (range; fg/μg). G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NS, not significant; TNF, tumour necrosis factor.