Table 2.
IGFBP3 mRNA levels for patients with breast cancer and with BBD
| Parameter | Tumor tissue | Adjacent tissue | ||
| No. of patients | IGFBP3 mRNA level | No. of patients | IGFBP3 mRNA level | |
| BBD | 96 | 248.1 (152.2, 496.5) | 60 | 178.9 (104.0, 322.7) |
| Breast cancer | 142 | 132.3 (89.3, 235.2) | 63 | 205.6 (157.1, 301.5) |
| pa | <0.001 | 0.763 | ||
| BBD | ||||
| Non-proliferative lesions | 57 | 185.4 (109.6, 314.2) | 34 | 157.4 (100.2, 243.2) |
| Proliferative lesions | 39 | 367.0 (217.2, 771.3) | 26 | 218.1 (137.6, 394.3) |
| pa | 0.002 | 0.044 | ||
| Breast cancer (by stage) | ||||
| 0 and I | 32 | 125.9 (103.0, 173.2) | 21 | 214.9 (106.4, 262.6) |
| IIa | 63 | 135.7 (89.6, 268.5) | 27 | 205.6 (158.9, 362.9) |
| IIb, III and IV | 47 | 141.1 (73.7, 328.9) | 15 | 199.4 (164.4, 320.7) |
| p for trend testa | 0.924 | 0.448 | ||
| Breast cancer (by ER status) | ||||
| Positive | 75 | 133.0 (89.3, 230.6) | 33 | 208.1 (165.1, 301.5) |
| Negative | 36 | 136.0 (77.6, 237.3) | 19 | 192.1 (155.2, 277.1) |
| Unknown | 31 | 125.8 (90.3, 359.0) | 11 | 214.9 (145.4, 742.1) |
| pa | 0.873 | 0.376 | ||
| Breast cancer (by PR status) | ||||
| Positive | 74 | 131.3 (89.3, 230.6) | 34 | 208.2 (167.1, 301.5) |
| Negative | 36 | 136.3 (77.6, 209.4) | 17 | 169.4 (155.2, 274.6) |
| Unknown | 32 | 136.0 (90.8, 355.4) | 12 | 193.5 (125.9, 534.7) |
| pa | 0.710 | 0.472 | ||
Results for IGFBP3 mRNA levels are shown as median (25th, 75th centile). BBD, benign breast disease; ER, estrogen receptor, IGFBP3, gene encoding insulin-like growth factor binding protein 3; PR, progesterone receptor. aAdjusted for age and menopausal status.