Table 2.

Alignment of amino acids at the substrate-binding pocket

	678	685	689	692	693	713	725	726	729	730	762
PDE10A2	V	T	A	I	Y	M	G	Q	F	Y	W
PDE1B	P	H	T	L	M	L	S	Q	F	I	N
PDE2	Q	T	A	I	Y	M	L	Q	F	M	W
PDE3	P	H	T	I	V	F	L	Q	F	I	W
PDE11	V	S	A	V	T	F	L	Q	W	I	W
PDE4	P	Y	T	I	M	M	S	Q	F	I	Y
PDE7	P	S	S	V	T	L	I	Q	F	M	W
PDE8	P	C	A	I	S	V	S	Q	F	I	W
PDE5	I	Q	A	V	A	M	M	Q	F	I	W
PDE6	I	Q	A	V	A	M	L	Q	F	I	W
PDE9	E	A	V	L	L	F	A	Q	F	I	Y