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Global structural changes induced by the binding of CPA. E2(CPA+CC) (yellow) and E2(TG+BHQ) (light green) crystal structures are superimposed with the M7–M10 helices. The structures are shown from the side opposite to that in Fig. 1. Arrows indicate the differences between the two structures. The circle indicates the amphipathic helix between M8 and M9. CPA is shown in space fill. M2, M5, and M7 are represented with two to three cylinders, although they are continuous helices.
