Table 1.
Levels of inhibition of the mRNA and protein expression of different viral genes in cells that expressed M1-TK, C-IE, or M1-IE, as compared to the levels of inhibition of cells that did not express a ribozyme (U373-MG)
HCMV gene | Viral gene class | Level of inhibition, %
|
|||
---|---|---|---|---|---|
U373-MG | M1-TK | C-IE | M1-IE | ||
IE1 mRNA | α | 0 | 1 | 8 | 85 ± 8 |
IE2 mRNA | α | 0 | 2 | 7 | 85 ± 8 |
US2 mRNA | β | 0 | 1 | 5 | 80 ± 6 |
IE1/IE2 protein | α | 0 | 2 | 4 | 88 ± 10 |
UL44 protein | β, γ | 0 | 1 | 3 | 80 ± 5 |
Glycoprotein B | β, γ | 0 | 0 | 3 | 80 ± 9 |
Glycoprotein H | γ | 0 | 2 | 1 | 80 ± 10 |
Values shown are the means from triplicate experiments. The values of standard deviation that are less than 5% are not shown.