Fig. 3.

Neutralizing antibodies in serial serum samples of individual patients. (A) Kinetic of neutralizing antibodies in serial serum samples of individual patients. Titers of anti-HCVpp neutralizing antibodies were determined by endpoint dilution of serial serum samples from 16 patients with resolved and 23 patients with chronic hepatitis C. Patients' identification numbers are indicated in boxes. Titers of neutralizing antibodies present in the early and late phase of infection in individual patients are connected through lines. (B) Plotting of sampling time (in days after infection) vs. neutralizing antibody titer during the acute phase of infection. Samples showing a titer of <1/20 were considered negative. The cutoff titer 1/20 is indicated by a dashed line.