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The analgesic effect of morphine on C57BL/6J control mice. A 20-min pretreatment with RANTES at two different doses inhibited the analgesic effect of morphine on the C57BL/6J mice. The antagonist ED50 of RANTES was 5.50 ng per mouse (95% confidence interval, 2.58–9.81). This antagonist effect of RANTES on morphine was reversed by a 2-h pretreatment of 50 ng of Met-RANTES per mouse before the RANTES injection. All injections were i.c.v.
