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. 2007 Mar 26;104(14):6061–6065. doi: 10.1073/pnas.0700295104

Table 2.

Morphine ED50 values in control and transgenic mouse models of sickle cell anemia

Mouse model ED50, 95% confidence interval
i.c.v., nmol/mouse i.t., nmol/mouse s.c., nmol/kg
C57BL/6J 2.70 (2.07–4.64) 0.088 (0.06–0.122) 6,470 (3,880–10,260)
NY1DD 3.95 (1.63–6.87) 0.085 (0.039–0.149) 2,360 (450–4,480)

The ED50 values were calculated by using a parallel line multiple regression assay. The individual values are based on the number of positive responses per total number of mice from three to four different doses of morphine.