Table 2.
Mouse model | ED50, 95% confidence interval |
||
---|---|---|---|
i.c.v., nmol/mouse | i.t., nmol/mouse | s.c., nmol/kg | |
C57BL/6J | 2.70 (2.07–4.64) | 0.088 (0.06–0.122) | 6,470 (3,880–10,260) |
NY1DD | 3.95 (1.63–6.87) | 0.085 (0.039–0.149) | 2,360 (450–4,480) |
The ED50 values were calculated by using a parallel line multiple regression assay. The individual values are based on the number of positive responses per total number of mice from three to four different doses of morphine.