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. 2007 Apr 10;4(4):e124. doi: 10.1371/journal.pmed.0040124

Figure 1. Expression Profile of TREM2 in Normal and Diseased CNS.

Figure 1

(A) Flow cytometry analysis of TREM2 (open tracings) expression on CD11b+ cells derived from the cortex of normal and EAE-diseased mice at day 4 after onset of clinical symptoms as well as from EAE-diseased mice at day 18 after onset of clinical symptoms. Isotype controls are shown in grey-filled tracings. TREM2 expression is detected on CD11b+ microglia/macrophages in the cortex of EAE-diseased mice. The percentages of TREM2+ cells are indicated in the upper-right corner of each histogram. Selected representative histograms are shown.

(B) Quantitative analysis of TREM2 expression on microglia by flow cytometry gated for CD11b+ cells. TREM2 expression is detected only on a minority of microglia and perivascular macrophages in the normal CNS tissue, but is up-regulated and detected in the spinal cord on the majority of CD11b+ cells at day 4 after onset of clinical symptoms of EAE. Data are presented as mean ± SEM. Tissues were derived from four EAE and four normal mice.