Fig. 6.
Differential mechanisms by which cholesterol and oxysterols trigger Insig binding to Scap, which in turn abrogates COPII binding to the MELADL sorting signal in Scap, inhibiting the ER-to-Golgi transport of SREBPs.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.