TABLE 1.
Reliability, Reproducibility, and Random Noise of Perfusion-weighted Imaging Measurements Obtained with Different Pulsed ASL Methods
| Brain Region and Measurement Parameter* |
DIPLOMA | EPISTAR | PICORE |
|---|---|---|---|
| Global brain | |||
| ICC† | 0.81 (0.61, 0.96) | 0.78 (0.41, 0.93) | 0.78 (0.40, 0.92) |
| WSC | 0.06 | 0.01 | 0.01 |
| Noise | 0.13 | 0.21 | 0.21 |
| CV (%) | 7.07 | 6.11 | 8.26 |
| Gray matter | |||
| ICC† | 0.80 (0.63, 0.96) | 0.75 (0.34, 0.92) | 0.76 (0.33, 0.92) |
| WSC | 0.09 | 0.01 | 0.01 |
| Noise | 0.11 | 0.24 | 0.23 |
| CV (%) | 6.77 | 6.13 | 8.42 |
| White matter | |||
| ICC† | 0.80 (0.50, 0.94) | 0.79 (0.44, 0.93) | 0.79 (0.40, 0.93) |
| WSC | 0.03 | 0.01 | 0.02 |
| Noise | 0.17 | 0.20 | 0.19 |
| CV (%) | 7.74 | 6.31 | 8.38 |
*
ICC, a measure of reliability; WSC, a measure of reproducibility; and noise are indexes of total variability and vary between 0 and 1. CV, an alternative measure of reproducibility, is a percentage of the mean value.
†
Numbers in parentheses are 95% confidence intervals. For the other measures, the confidence intervals (not listed) scale with the ratio of their mean values to the mean value of the ICC.