TABLE 2.

Reliability, Reproducibility, and Random Noise of Labeled Echo-planar MR Imaging Measurements Obtained with Different Pulsed ASL Methods

Brain Region and Measurement Parameter*	DIPLOMA	EPISTAR	PICORE
Global brain
ICC†	0.98 (0.94, 0.99)	0.98 (0.93, 0.99)	0.96 (0.88, 0.99)
WSC	<0.01	<0.01	<0.01
Noise	<0.02	<0.02	<0.04
Gray matter
ICC†	0.96 (0.88, 0.99)	0.97 (0.90, 0.99)	0.94 (0.80, 0.98)
WSC	<0.01	<0.01	<0.01
Noise	<0.03	<0.03	<0.06
White matter
ICC†	0.99 (0.97, 0.99)	0.99 (0.96, 0.99)	0.98 (0.93, 0.99)
WSC	<0.01	<0.01	<0.01
Noise	<0.01	<0.01	<0.02

^*Perfusion-weighted images were obtained by subtracting the labeled from the nonlabeled echo-planar imaging data. ICC, a measure of reliability; WSC, a measure of reproducibility; and random noise are indexes of total variability and vary between 0 and 1.

^†Numbers in parentheses are 95% confidence intervals.