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. 2007 Mar 26;7:2. doi: 10.1186/1472-6793-7-2

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Copyright © 2007 Provenzano et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Maximum force values at 3 weeks (mean ± S.E.M.). Maximum force was significantly decreased in tissues from hindlimb unloaded (HU) animals receiving saline when compared to tissues from Amb + Sal animals (p = 0.03). The addition of IGF-I significantly improved maximum force in tissues from ambulatory healing animals when compared to tissues from ambulatory healing animals that received saline (p = 0.0002). Addition of IGF-I and GH+IGF-I in HU animals significantly increased maximum force values when compared to hindlimb unloaded animals receiving saline (p = 0.0074 and p = 0.0013, respectively). a significantly different from Sham group; b significantly different from Amb + Sal group; c significantly different from HU + Sal group.