Figure 6.

Inhibition of HCV replication in infected cells by human IFN-α and IFN-λ. Naïve HFHs were infected by medium of transfected cells as described in Figure 5. A shows the HCV levels in cultures maintained without IFN during an 18-day period after infection. B and C show HCV levels in infected HFHs maintained in medium containing human 1 IU/ml IFN-α and 100 ng/ml IFN-λ1, respectively. Interferons were added to the naïve HFHs 1 day before the start of the 2-day infection period. Virus levels at the time of infection are labeled as CC (see legend to Figure 5 and Materials and Methods).