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Glucocorticoids disrupt the osteoclast cytoskeleton. Osteoclasts, generated on dentin in the presence and absence of dexamethasone (DEX), were stained with FITC-phalloidin to visualize the actin cytoskeleton. The well-demarcated actin rings present in naïve osteoclasts are disrupted by the glucocorticoid (reprinted with permission from the J Clin Invest 2006, 116:2152–2160).84
