Figure 2.
Effect of rapsyn overexpression on total membrane AChR concentration in control rats and in chronic EAMG rats. The AChR concentration of untreated and rapsyn-treated tibialis anterior muscles was measured in five control and 10 chronic EAMG rats by radioimmunoassay using 125I-labeled α-BT. A: Average AChR concentration in the tibialis anterior muscles in untreated muscles (white bars) and rapsyn-treated muscles (black bars). B: The effect of anti-rat AChR antibody titer on AChR levels. Open circles indicate the total AChR of untreated muscles; filled circles correspond to total AChR of rapsyn-treated muscles. All rapsyn-treated muscles had an increased amount of total AChR compared with the untreated muscle of the same animal.