Table 2.
Morphometric Analysis of Endplates
| Regions analyzed* | Nerve bouton area (μm2) | Presynaptic membrane length (μm) | Postsynaptic membrane length (μm) | Membrane length ratio (postsynaptic/ presynaptic) | |
|---|---|---|---|---|---|
| Untreated control | 76 | 5.9 ± 1.8 | 5.8 ± 1.8 | 24.7 ± 11.7 | 4.5 ± 0.9 |
| Rapsyn-treated control | 65 | 5.3 ± 2.6 | 4.9 ± 1.3 | 20.1 ± 7.8 | 4.0 ± 0.3 |
| Untreated EAMG | 57 | 5.0 ± 2.3 | 5.2 ± 1.1 | 12.7 ± 3.0† | 2.5 ± 0.3† |
| Rapsyn-treated EAMG | 24 | 6.9 ± 4.6 | 5.5 ± 1.7 | 8.1 ± 2.2‡ | 1.5 ± 0.02‡ |
Mean ± SD of three muscles for each condition.
*
A region here refers to an area of one synaptic bouton and the adjacent postsynaptic membrane.
†
Significantly different from untreated control endplates (P < 0.05) and significantly different from rapsyn-treated EAMG endplates (P < 0.05).
‡
Significantly different from all other conditions (P < 0.05) and other differences in this table are not significant (P> 0.05).