Figure 1.
MMP-2 and MMP-9 mRNA expression in steatotic livers. A: MMP-2 mRNA expression was found relatively undisturbed in all studied groups at day 1 (lanes 2 and 3), day 3 (lanes 4 and 5), and day 7 (lanes 6 and 7) post-OLT, including naïve steatotic livers (lane 1). On the contrary, MMP-9 mRNA expression, which was virtually absent in naïve steatotic livers (lane 1), was found highly expressed in control steatotic OLTs (lanes 2, 4, and 6) and only slightly expressed in CS1-treated OLTs (lanes 3, 5, and 7). B: Densitometric analyses showed that MMP-9 mRNA expression was decreased by 4- to 10-fold in CS1 peptide-treated OLTs compared with respective controls. Results are presented as mean ± SD (n = 5/group, *P < 0.01, **P < 0.02).