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. Author manuscript; available in PMC: 2007 Apr 12.
Published in final edited form as: Exp Neurol. 2006 Sep 12;203(1):185–195. doi: 10.1016/j.expneurol.2006.08.004

Figure 6.

Figure 6

Chondroitinase treatment decreases extrafascicular retrograde regeneration. Adult rats received bilateral sciatic nerve transection and end-to-end repair (neurorrhaphy). One nerve was injected with chondroitinase ABC and the contralateral nerve treated with vehicle alone (control). After 28 weeks, neurofilament-immunopositive axons were counted 3mm proximal to the repair site. (A) Intrafascicular retrograde regeneration (IRR) was evident by an increase in axon count within repaired nerves when compared to normal nerves. Results indicate approximately 25% of the axons found within the nerve proper proximal to the repair were attributed to retrograde axonal growth. IRR was not altered significantly by chondroitinase treatment applied at the site of nerve transection repair. (B) Extrafasciclular retrograde regeneration (ERR) was scored by direct count of neurofilament-immunopositive axons found outside the nerve proper 3mm proximal to the repair. For repaired nerves injected with chondroitinase the mean number of ERR axons was a reduced significantly (P < 0.01, t-test). Data represent the means (±SE) of 9 nerves in each condition.