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. Author manuscript; available in PMC: 2007 Apr 12.
Published in final edited form as: Genes Dev. 2004 Jan 15;18(2):117–125. doi: 10.1101/gad.1165904

Figure 5.

Figure 5

The role of Mus81* in creating COs without HJs. Model III proposes that meiotic SEI intermediates have three fates depending on the organism and pathway choice. All organisms use SDSA to produce NCOs (center). Class I interfering COs occur in organisms containing MSH4–MSH5 and arise from the DSBR pathway (left). Class II noninterfering COs are proposed to arise from the action of Mus81* on an SEC intermediate (right). The SEC intermediate provides targets for Mus81* cleavage at the D-loop and at the half-junction (light dotted arrows). Cleavage at these sites results in an obligatory CO product containing 5′-flaps and gaps. Here the flaps are shown to isomerize into 3′-flaps prior to cleavage by a second round of Mus81* action. Filling-in of the gaps and ligation completes the CO product (not shown).