. Author manuscript; available in PMC: 2007 Apr 12.

Published in final edited form as: J Biol Chem. 2007 Jan 21;282(12):9150–9161. doi: 10.1074/jbc.M609304200

Table III.

Increased Hex A and S activities in the enriched lysosomal fraction, LYSO, in relation to postnuclear supernatant (PNS) fraction in a domain I β-mutant, βC137Y/C137Y, cell line treated with PYR.

Regimen	PYR^B		Control (ETOH only)

*Fractions*	*PNS*	*LYSO*	*PNS*	*LYSO*
Hex A^B,^C	125^A	205^A	80.5	97.4
Hex S^D	122^A	237^A	75.5	117
Lysate^D	409^A	1140^A	173	385

P < 0.05.

3.0 μg/mL,

The difference in Hex A activity between the PNS and LYSO fractions of PYR-treated cells was significantly higher than the difference observed in control cells (P < 0.01),

Units: hydrolyzed MU-nmoles/hr/mg total protein.