Table 3.

 Additive effect of component end points on composite end points, based on category of importance to patients (in composite end points with moderate/large gradient in importance) (n=46)

Outcome	Most important components (CI, CII)*	Moderately important components added (CIII)†	Less important components added (CIV, CV)‡
Median % (IQR) event rate of composite end point for control group	2.5 (0.8-6.1)	8.7 (5.2-14.5)	21.7 (13.1-33.2)
Median % (IQR) effect of treatment (RRR)	13 (−14-41)	17 (−9-36)	24 (8-42)

CI=category I (death); CII=category II (critical); CIII=category III (major); CIV=category IV (moderate); CV=category V (minor); IQR=interquartile range; RRR=relative risk reduction.

*Reflects event rate in control group and RRR for only most important components included in composite end point.

†Moderate components, when present (n=35), have been included with most important components to calculate event rate in control group and RRR.

‡Event rate in control group and RRR results for full composite end point; reflects addition of least important components to data in previous column.