Table 1.

Paralog sequence similarity of fugu protocadherin subclusters

	5' low homology region			3' high homology region
Paralog subclustersa	Pcdh protein sequenceb	Amino acid identityc (%)	Nucleotide identityd (%)	Pcdh protein sequenceb	Amino acid identityc (%)	Nucleotide identityd (%)
FrPcdh2α2–7	1–331	80.0 ± 13.4	79.0 ± 13.9	332–777	99.3 ± 0.3	99.3 ± 0.2
FrPcdh2α8–25	1–507	67.6 ± 10.8	69.9 ± 9.9	508–759	99.4 ± 0.3	99.1 ± 0.2
FrPcdh2α26–36	1–487	57.5 ± 6.6	60.7 ± 5.1	488–770	99.4 ± 0.3	99.4 ± 0.3
FrPcdh2γ1–17	1–356	70.0 ± 10.8	72.7 ± 10.0	357–764	99.6 ± 0.3	99.3 ± 0.3
FrPcdh2γ19–32'	1–507	66.4 ± 9.0	68.2 ± 8.5	508–781	99.3 ± 0.3	99.3 ± 0.2
FrPcdh2γ33'-36'	1–449	66.5 ± 9.5	68.7 ± 7.3	450–792	99.3 ± 0.6	99.6 ± 0.3

^a The fugu Pcdh sequences used for this analysis do not include the coding sequences for the signal peptide.

^b The numbers refer to the consensus of the amino acid sequence alignment without the signal peptide sequence

^c The amino acid sequence identity is calculated by average of the pair-wise comparison of paralog members in the same subcluster and expressed as mean ± standard deviation.

^d Nucleotide sequences were aligned according to the amino acid alignment and the percentage identity is calculated by average of the pair-wise comparison and expressed as mean ± standard deviation.