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Effect of monomeric gp120 on CD4+ T-cell proliferation
| No Env | IIIB gp120 | SF162 gp120 | |
|---|---|---|---|
| CD4+ cells undergoing proliferation, % | 15.3 | 14.4 | 12.5 |
| CD4− cells undergoing proliferation, % | 7.7 | 7.4 | 7.3 |
Anti-CD3 mAb (0.5 μg/mL) stimulated CFSE-labeled PBMCs were exposed to 2 μg/mL IIIB or SF162 gp120 or left untreated. CD4+ T cells were monitored for proliferation 4 days after coculture by flow cytometry and expressed as percentage of total CD4+ T cells.
